Penicillin in the treatment of chancroidal bubo.
نویسنده
چکیده
INTRODUCTION CHANCROID encountered in this area presented as multiple penile sores with, in many cases, a large painful unilateral fluctuant bubo. It was at this time customary to treat such cases with sulphonamides and repeated aspiration of the bubo~ It was found that in an analysis of approximately one hundred cases of chancroid with fluctuant buboes, none was required to be kept in hospital for less than four weeks, and many were kept for as long as five to six weeks. Even when treatment was modified by the use of bubo lavage with mercurochrome, the length of stay in hospital was not significantly shortened. In an attempt to discover some method of reducing the time spent in hospital, it was decided to investigate the effect of penicillin in the condition. There is conflicting opinion as to the efficacy of penicillin in chancroid. McElligott (1950) and McLachlan (1951) state that it is ineffective. Combes (1945) quotes Canizares as having observed the worsening of lesions following systemic administration of penicillin. Studies in vitro by Jennings (1949) indicate that Hcemophilus ducreyi is sensitive to penicillin in a concentration of from 0.075 to 0.25 unitsjml. Further, there is of course the danger of masking a concomitant Treponema pallidum infection.
منابع مشابه
Anti-chancroidal drugs tested by the hetero-inoculation of bubo fluid from the treated donor.
The effectiveness of different drugs in the experimental chancroidal infection in man may be tested by a number of means. One way is to reproduce the clinical condition by intradermal inoculation and to treat the developed lesion. This method has little advantage to offer over that of treating the clinical infection, for each volunteer is automatically a ' take'. More satisfactory methods are:
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عنوان ژورنال:
- Journal of the Royal Army Medical Corps
دوره 100 2 شماره
صفحات -
تاریخ انتشار 1954